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FLASH GENE
Symbol KIF1A contributors: mct/npt/shn - updated : 03-05-2015
HGNC name kinesin family member 1A
HGNC id 888
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal globular domain
  • a forkhead-associated (FHA) domain
  • a motor domain
  • an ATP and the microtubule binding sites
  • a long alpa-helical coiled-coil region (CC2, stalk region), involved in dimerization
  • a small C terminal domain, potentially involved in interaction with other proteins, vesicles or organelles
    • mono polymer monomer
    HOMOLOGY
    interspecies ortholog to Kif1a, Mus musculus
    ortholog to Kif1a, Rattus norvegicus
    ortholog to kif1a, Danio rerio
    ortholog to KIF1A, Pan troglodytes
    Homologene
    FAMILY
  • kinesin 3 family
    • CATEGORY motor/contractile , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text axonal synaptic vesicles
    basic FUNCTION
  • axonal transporter of synaptic vesicles
  • microtubule associated motor protein
  • the fast anterograd transporter in axons
  • involved in nuclear migration and neurogenesis, suggesting a cell cycle-dependent switch between distinct microtubule motors driving interkinetic nuclear migration
  • remains associated with Dense-core vesicles (DCVs) during retrograde DCV transport, in hippocampal neurons
  • is indispensable for BDNF-mediated hippocampal synaptogenesis and learning enhancement induced by enrichment
  • plays prominent roles in axonal transport and synaptogenesis
  • KIF1A or KIF1C must have an effect on the cycle of division before differentiation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • anterograde motor protein that transports membranous organelles along axonal microtubules
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Liprin-alpha/SYD-2
  • intramolecular interaction in KIF1A between the forkhead-associated (FHA) domain and a coiled-coil domain (CC2)
  • Herpes simplex virus type 2 membrane protein UL56
  • DCX is essential for the function of KIF1a, a kinesin-3 motor protein that traffics synaptic vesicles
  • DCLK1 guides KIF1A-mediated cargo transport to dendrites
    • cell & other
    REGULATION
    inhibited by intramolecular interaction between the FHA domain and a coiled coil domain (CC2)
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL2Q37 , SPG30 , HSN2C , MRD9
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by promoter methylation, associated with breast cancer and inversely associated with DNA repair capacity (DRC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for autism/behaviordisorder/eczema in the del2q37 syndrome
    Marker
    Therapy target
    ANIMAL & CELL MODELS