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FLASH GENE

Symbol

WRN

contributors: mct/ - updated : 23-08-2019

HGNC name	Werner syndrome, RecQ helicase-like
HGNC id	12791

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

WRN

related resource

Werner Syndrome mutation database

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation       missense mutations or polymorphisms could promote genetic instability and cancer by selectively interfering with recombination in somatic cells tumoral     --low   deficiency is associated with accumulation of gaps and breaks at common fragile sites even under unperturbed conditions

Susceptibility

to age related disorders such as atherosclerosis to enhanced longevity

Variant & Polymorphism SNP	L1074F, C1367R

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer head and neck   RECQL and WRN proteins are potential therapeutic targets in head and neck squamous cell carcinoma

ANIMAL & CELL MODELS