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FLASH GENE
Symbol TLE1 contributors: mct/pgu - updated : 19-01-2013
HGNC name transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
HGNC id 11837
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • casein kinase II site/nuclear localization sequence motif
  • a pleckstrin homology (PH) domain
  • six WD repeats (Trp-Asp domains)
    • HOMOLOGY
    interspecies homolog to Drosophila split Groucho (Notch signaling pathway)
    homolog to murine Tle1
    Homologene
    FAMILY
  • WD repeat Groucho/TLE family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text
  • nuclear retention of TLE proteins requires HHEX to bind to both TLE and DNA
  • subnuclear localization of TLE1 plays an important role in transcriptional repression by HHEX
    • basic FUNCTION
  • negative regulator of CBFA2 (AML1)
  • may be a cofactor in ERR-gamma-mediated transcriptional regulation
  • transcriptional corepressor that inhibits Wnt signaling and other cell fate determination signals, and so have an established role in repressing differentiation
  • functions with RUNX2 in epigenetic repression of ribosomal RNA genes
  • with RUNX2, and UBTF together occupy nucleolar organizing regions (NORs) during mitosis and control histone modifications
  • might plays roles independently of HESX1 by interacting with other transcription factors
  • co-repressor that involves many signaling pathways like cell survival, hematopoiesis and differentiation
  • critical factor for the survival of synovial sarcomas
  • plays a critical role in the regulation of neurogenesis by inhibiting the differentiation of neural progenitor cells into neurons
  • is necessary for the maintenance of neuronal survival
  • Groucho-related transcriptional repressor protein that exerts survival and antiapoptotic function in several cellular systems and has been implicated in the pathogenesis of cancer
  • regulator of anoikis in normal mammary epithelial and breast carcinoma cells
  • novel role for TLE1 in the maintenance of anoikis resistance in breast cancer cells
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • coexpressed with NOTCH implicating these molecules in the maintenance of the undifferentiated state in epithelial cells
  • interacting with ERR-gamma
  • associates with rRNA genes during mitosis and interphase through interaction with RUNX2
  • interacting with HESX1 and repressing PROP1 activity
  • TLE1 cooperates with FOXG1 to promote neuronal survival in a CK2- and PI3K-AKT-dependent manner
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    epigenetic inactivation contributes to the development of hematologic malignancies by disrupting critical differentiation and growth-suppressing pathways
    Susceptibility
    Variant & Polymorphism
    Candidate gene marker for synovial sarcoma
    Marker
    Therapy target
    ANIMAL & CELL MODELS