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FLASH GENE

Symbol

TLE1

contributors: mct/pgu - updated : 19-01-2013

HGNC name	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
HGNC id	11837

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Digestive liver       predominantly Lymphoid/Immune spleen       moderately Nervous brain       highly Homo sapiens Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid         Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol   epithelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

growth/childhood, pregnancy

Text	placenta, moderately
	expressed highly in the postnatal brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	casein kinase II site/nuclear localization sequence motif
	a pleckstrin homology (PH) domain
	six WD repeats (Trp-Asp domains)

HOMOLOGY

interspecies	homolog to Drosophila split Groucho (Notch signaling pathway)
	homolog to murine Tle1

Homologene

FAMILY

WD repeat Groucho/TLE family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm
text	nuclear retention of TLE proteins requires HHEX to bind to both TLE and DNA
	subnuclear localization of TLE1 plays an important role in transcriptional repression by HHEX

basic FUNCTION	negative regulator of CBFA2 (AML1)
	may be a cofactor in ERR-gamma-mediated transcriptional regulation
	transcriptional corepressor that inhibits Wnt signaling and other cell fate determination signals, and so have an established role in repressing differentiation
	functions with RUNX2 in epigenetic repression of ribosomal RNA genes
	with RUNX2, and UBTF together occupy nucleolar organizing regions (NORs) during mitosis and control histone modifications
	might plays roles independently of HESX1 by interacting with other transcription factors
	co-repressor that involves many signaling pathways like cell survival, hematopoiesis and differentiation
	critical factor for the survival of synovial sarcomas
	plays a critical role in the regulation of neurogenesis by inhibiting the differentiation of neural progenitor cells into neurons
	is necessary for the maintenance of neuronal survival
	Groucho-related transcriptional repressor protein that exerts survival and antiapoptotic function in several cellular systems and has been implicated in the pathogenesis of cancer
	regulator of anoikis in normal mammary epithelial and breast carcinoma cells
	novel role for TLE1 in the maintenance of anoikis resistance in breast cancer cells

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	coexpressed with NOTCH implicating these molecules in the maintenance of the undifferentiated state in epithelial cells
	interacting with ERR-gamma
	associates with rRNA genes during mitosis and interphase through interaction with RUNX2
	interacting with HESX1 and repressing PROP1 activity
	TLE1 cooperates with FOXG1 to promote neuronal survival in a CK2- and PI3K-AKT-dependent manner

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function epigenetic inactivation contributes to the development of hematologic malignancies by disrupting critical differentiation and growth-suppressing pathways

Susceptibility

Variant & Polymorphism

Candidate gene	marker for synovial sarcoma
Marker
Therapy target

ANIMAL & CELL MODELS