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FLASH GENE

Symbol

FCN1

contributors: npt/ - updated : 29-06-2007

HGNC name	ficolin (collagen/fibrinogen domain containing) 1
HGNC id	3623

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES		globular
STRUCTURE

motifs/domains	a leader peptide, a short N-terminal segment
	a collagen-like region
	a C-terminal fibrinogen-like domain

conjugated

GlycoP

mono polymer

homomer , polymer

HOMOLOGY

interspecies	ortholog to murine Fcna
	homolog to Drosophila CG5550

intraspecies

homolog to FCN2

Homologene

FAMILY

ficolin lectin family

CATEGORY

immunity/defense , signaling growth factor

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic,granule
text	localized in secretory granules in the cytoplasm of neutrophils, monocytes, and type II alveolar epithelial cells in lung

basic FUNCTION	functioning as a plasma protein with elastin-binding activity
	involved in serum exerting lectin activity
	like its family members, functions as a recognition molecule of the lectin complement pathway and plays an important role in innate immunity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

text	antimicrobial tumoral response (sensu invertebrata)

PATHWAY

metabolism

signaling

a component

complexing with MASP1 and MASP2

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein	binding to TGFB1 and elastin
	CRP binding is enhanced by conformational bending at the neck region of FCN1, to avoid steric hindrance by the COL domain (Tanio 2009)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS