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FLASH GENE

Symbol

FCN1

contributors: npt/ - updated : 29-06-2007

HGNC name	ficolin (collagen/fibrinogen domain containing) 1
HGNC id	3623

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	8.37 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
text structure	five polymorphisms in the promoter region

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002003 9 - 1313 NP_001994 - 326 - -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen           thymus         Respiratory lung       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage
cell lines
fluid/secretion	plasma

at STAGE

PROTEIN

PHYSICAL PROPERTIES		globular
STRUCTURE

motifs/domains	a leader peptide, a short N-terminal segment
	a collagen-like region
	a C-terminal fibrinogen-like domain

conjugated

GlycoP

mono polymer

homomer , polymer

HOMOLOGY

interspecies	ortholog to murine Fcna
	homolog to Drosophila CG5550

intraspecies

homolog to FCN2

Homologene

FAMILY

ficolin lectin family

CATEGORY

immunity/defense , signaling growth factor

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic,granule
text	localized in secretory granules in the cytoplasm of neutrophils, monocytes, and type II alveolar epithelial cells in lung

basic FUNCTION	functioning as a plasma protein with elastin-binding activity
	involved in serum exerting lectin activity
	like its family members, functions as a recognition molecule of the lectin complement pathway and plays an important role in innate immunity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

text	antimicrobial tumoral response (sensu invertebrata)

PATHWAY

metabolism

signaling

a component

complexing with MASP1 and MASP2

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein	binding to TGFB1 and elastin
	CRP binding is enhanced by conformational bending at the neck region of FCN1, to avoid steric hindrance by the COL domain (Tanio 2009)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS