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FLASH GENE

Symbol

MMP8

contributors: mct - updated : 01-09-2021

HGNC name	matrix metalloproteinase 8 (neutrophil collagenase)
HGNC id	7175

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in ovarian cancer with invasive potential constitutional       gain of function in chronic obstructive pulmonary disease constitutional     --over   at the site of abdominal aortic aneurysm rupture tumoral somatic mutation       five mutations reducing MMP enzyme activity in melanoma (Palavalli 2009) constitutional     --over   intraplaque MMP8 levels are increased in asymptomatic patients with carotid plaque progression on ultrasound (Turu 2006) constitutional     --over   increased local MMP8 expression in the periodontal connective tissues of smokers with periodontal disease (Liu 2006) constitutional     --over   serum MMP-8 concentrations are elevated in prevalent or subclinical atherosclerosis and associate with the worst cardiovascular outcome in men (Tuomainen 2007)

Susceptibility

to preterm premature rupture of membranes bacterial vaginosis is associated with increased levels of matrix metalloproteinase-8(MMP-8) in vaginal fluid of pregnant women (Diaz-Cueto 2006) to osteonecrosis of the femoral head (ONFH)

Variant & Polymorphism SNP , other	SNP associated with preterm premature rupture of membranes
	a promoter SNP with its minor allele (T) associating with reduced susceptibility to lymph node metastasis in breast cancer (Decock 2007)
	polymorphism +17 C/G in matrix metalloprotease MMP8 decreases lung cancer risk (González-Arriaga 2008)
	remarkable association between rs11225394 in MMP8 gene and an increased risk of ONFH and a significant association between MMP8 rs2012390 and the decreased risk of ONFH

Candidate gene
Marker	increase in the duration of response to the cold test was associated with an increase in MMP8 levels in teeth with pulpitis
Therapy target

ANIMAL & CELL MODELS