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FLASH GENE
Symbol MMP8 contributors: SGE/npt - updated : 15-06-2009
HGNC name matrix metalloproteinase 8 (neutrophil collagenase)
HGNC id 7175
Location 11q22.2      Physical location : 102.582.525 - 102.595.685
Synonym name
  • PMNL collagenase
  • neutrophil collagenase
  • Synonym symbol(s) HNC, CLG1, PMNL-CL, MMP-8
    EC.number 3.4.24.34
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text member of the MMP cluster
    STRUCTURE 12.33 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3056 41.9 467 - Hasty (1990)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
    Reproductivefemale systemplacenta   
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticneutrophil
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text cytotrophoblastic cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four hemoplexin-like domains
  • conjugated HemoP , MetalloP
    HOMOLOGY
    interspecies homolog to rattus Mmp8 (72.9pc)
    homolog to murine Mmp8 (74.5pc)
    Homologene
    FAMILY
  • peptidase M10A family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text secreted, extracellular space, extra cellular matrix
    basic FUNCTION
  • regulator in matrix remodeling
  • degradation of type I, II, III collagens, preferentially the type I collagen
  • degrading fibrillar collagens imparting strength to the fetal membranes
  • abilitiy to inhibit melanoma progression (Palavalli 2009)
  • has an inhibitory effect on cancer metastasis (Decock 2007)
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • binding two ions Zn2+ per subunit
  • binding three ions Ca2+ per subunit
  • protein
  • binding TIMPs in a 1:1 stoechiometry
  • cell & other
    REGULATION
    activated by autocatalytic cleavage
    inhibited by TIMPs and TFPI2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian cancer with invasive potential
    constitutional       gain of function
    in chronic obstructive pulmonary disease
    constitutional     --over  
    at the site of abdominal aortic aneurysm rupture
    tumoral somatic mutation      
    five mutations reducing MMP enzyme activity in melanoma (Palavalli 2009)
    constitutional     --over  
    intraplaque MMP8 levels are increased in asymptomatic patients with carotid plaque progression on ultrasound (Turu 2006)
    constitutional     --over  
    increased local MMP8 expression in the periodontal connective tissues of smokers with periodontal disease (Liu 2006)
    constitutional     --over  
    serum MMP-8 concentrations are elevated in prevalent or subclinical atherosclerosis and associate with the worst cardiovascular outcome in men (Tuomainen 2007)
    Susceptibility
  • to preterm premature rupture of membranes
  • bacterial vaginosis is associated with increased levels of matrix metalloproteinase-8(MMP-8) in vaginal fluid of pregnant women (Diaz-Cueto 2006)
  • Variant & Polymorphism SNP , other
  • SNP associated with preterm premature rupture of membranes
  • a promoter SNP with its minor allele (T) associating with reduced susceptibility to lymph node metastasis in breast cancer (Decock 2007)
  • polymorphism +17 C/G in matrix metalloprotease MMP8 decreases lung cancer risk (González-Arriaga 2008)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS