| Symbol
| NPTX2
| contributors: mct/shn - updated : 29-03-2022
|
| HGNC name
| neuronal pentraxin II
|
| HGNC id
| 7953
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --over
|
| |
pancreatic cancer cytology samples had statistically significant higher levels of NPTX2 methylation compared with benign diseases | | constitutional
|
|
| --low
|
|
in frontotemporal dementia  | | tumoral
|
|
| --over
|
| |
can promote the proliferation, invasion, migration and tumorigenesis of Epithelial ovarian cancer (EOC) via IL6-JAK2/STAT3 signaling pathway | | tumoral
|
|
| --low
|
| |
by hypermethylation in over 90p100 primary pancreatic cancer tissues but rarely in normal pancreatic ductal epithelia | |
Variant & Polymorphism
| 
| |
Candidate gene
| Marker
| NPTX2 is a marker of poor prognosis for neuroblastoma patients | |
NPTX2 is a promising synapse-derived disease progression biomarker in genetic in frontotemporal dementia (FTD) | |
serum NPTX2 level may be a novel predictor for cognitive function in vascular dementia (VaD) | |
detection of aberrant methylation of NPTX2 in pure pancreatic juice samples could be useful as a molecular marker to discriminate between patients with malignant and benign disease of the pancreas | Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| cancer | reproductive | ovary | |
| act as a promising treatment target for EOC molecular therapy |
| | |
|
| Mice lacking Narp showed a marked increase in sensitivity to kindling-induced seizure |