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FLASH GENE

Symbol

NPTX2

contributors: mct/shn - updated : 29-03-2022

HGNC name	neuronal pentraxin II
HGNC id	7953

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002523 5 - 2738 NP_002514 - 431 highly enriched at excitatory synapses - 20729843

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       lowly Homo sapiens Digestive liver       lowly Homo sapiens Endocrine pancreas       highly Homo sapiens Nervous brain       highly Homo sapiens Reproductive male system seminal vesicles     highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three glycosylation sites
	a putative leucine zipper domain

HOMOLOGY

interspecies	ortholog to Nptx2, Mus musculus
	ortholog to Nptx2, Rattus norvegicus
	ortholog to nptx2, Danio rerio
	ortholog to NPTX2, Pan troglodytes

Homologene

FAMILY

neuronal pentraxins

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	promotes neurite outgrowth
	contributes to homeostatic plasticity of interneurons and is important for the activity-dependent recruitment of PV-IN–mediated inhibition
	essential role for NPTX2, NPTXR in controlling network dynamics highlighting potential therapeutic targets for disorders with inhibition/excitation imbalances such as schizophrenia
	NPTX2 is a novel PNN binding protein with a role in the mechanism of perineuronal net (PNN), a mesh-like proteoglycan structure on the neuronal surface which is involved in regulating plasticity formation
	is an immediate-early gene that has been shown to play a critical role in guiding synaptic plasticity
	NPTX2 function requires activity-dependent exocytosis and dynamic shedding at synapses and is coupled to circadian behavior

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

nervous system , synaptogenesis

text	involved in excitatory synapse formation

PATHWAY

metabolism

signaling

a component

component of three neuronal pentraxins (represent a novel neuronal uptake pathway that may function during synapse formation and remodeling)

INTERACTION

DNA

RNA

small molecule

protein	taipoxin and taipoxin-associated calcium-binding protein 49, TCBP49
	form heterocomplexes with neuronal pentraxin 1, NP1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   pancreatic cancer cytology samples had statistically significant higher levels of NPTX2 methylation compared with benign diseases constitutional     --low   in frontotemporal dementia tumoral     --over   can promote the proliferation, invasion, migration and tumorigenesis of Epithelial ovarian cancer (EOC) via IL6-JAK2/STAT3 signaling pathway tumoral     --low   by hypermethylation in over 90p100 primary pancreatic cancer tissues but rarely in normal pancreatic ductal epithelia

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	NPTX2 is a marker of poor prognosis for neuroblastoma patients
	NPTX2 is a promising synapse-derived disease progression biomarker in genetic in frontotemporal dementia (FTD)
	serum NPTX2 level may be a novel predictor for cognitive function in vascular dementia (VaD)
	detection of aberrant methylation of NPTX2 in pure pancreatic juice samples could be useful as a molecular marker to discriminate between patients with malignant and benign disease of the pancreas
Therapy target
	System Type Disorder Pubmed cancer reproductive ovary act as a promising treatment target for EOC molecular therapy

ANIMAL & CELL MODELS

Mice lacking Narp showed a marked increase in sensitivity to kindling-induced seizure