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FLASH GENE
Symbol NPTX2 contributors: mct/shn - updated : 29-03-2022
HGNC name neuronal pentraxin II
HGNC id 7953
Location 7q22.1      Physical location : 98.246.596 - 98.259.181
Synonym name
  • neuronal activity-regulated pentaxin
  • apexin
  • neuronal pentraxin-2
    • Synonym symbol(s) NP2, NARP, NP-II
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text Immediate-early gene (IEG) dynamically regulated by forms of synaptic activity
    STRUCTURE 12.59 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map cen - D7S491 - D7S554 - NPTX2 - D7S651 - D7S2498 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2738 - 431 highly enriched at excitatory synapses - 20729843
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly Homo sapiens
    Digestiveliver   lowly Homo sapiens
    Endocrinepancreas   highly Homo sapiens
    Nervousbrain   highly Homo sapiens
    Reproductivemale systemseminal vesicles  highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three glycosylation sites
  • a putative leucine zipper domain
    • HOMOLOGY
    interspecies ortholog to Nptx2, Mus musculus
    ortholog to Nptx2, Rattus norvegicus
    ortholog to nptx2, Danio rerio
    ortholog to NPTX2, Pan troglodytes
    Homologene
    FAMILY neuronal pentraxins
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • promotes neurite outgrowth
  • contributes to homeostatic plasticity of interneurons and is important for the activity-dependent recruitment of PV-IN–mediated inhibition
  • essential role for NPTX2, NPTXR in controlling network dynamics highlighting potential therapeutic targets for disorders with inhibition/excitation imbalances such as schizophrenia
  • NPTX2 is a novel PNN binding protein with a role in the mechanism of perineuronal net (PNN), a mesh-like proteoglycan structure on the neuronal surface which is involved in regulating plasticity formation
  • is an immediate-early gene that has been shown to play a critical role in guiding synaptic plasticity
  • NPTX2 function requires activity-dependent exocytosis and dynamic shedding at synapses and is coupled to circadian behavior
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system , synaptogenesis
    text involved in excitatory synapse formation
    PATHWAY
    metabolism
    signaling
    a component component of three neuronal pentraxins (represent a novel neuronal uptake pathway that may function during synapse formation and remodeling)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • taipoxin and taipoxin-associated calcium-binding protein 49, TCBP49
  • form heterocomplexes with neuronal pentraxin 1, NP1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    pancreatic cancer cytology samples had statistically significant higher levels of NPTX2 methylation compared with benign diseases
    constitutional     --low  
    in frontotemporal dementia
    tumoral     --over  
    can promote the proliferation, invasion, migration and tumorigenesis of Epithelial ovarian cancer (EOC) via IL6-JAK2/STAT3 signaling pathway
    tumoral     --low  
    by hypermethylation in over 90p100 primary pancreatic cancer tissues but rarely in normal pancreatic ductal epithelia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • NPTX2 is a marker of poor prognosis for neuroblastoma patients
  • NPTX2 is a promising synapse-derived disease progression biomarker in genetic in frontotemporal dementia (FTD)
  • serum NPTX2 level may be a novel predictor for cognitive function in vascular dementia (VaD)
  • detection of aberrant methylation of NPTX2 in pure pancreatic juice samples could be useful as a molecular marker to discriminate between patients with malignant and benign disease of the pancreas
    • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    act as a promising treatment target for EOC molecular therapy
    ANIMAL & CELL MODELS
  • Mice lacking Narp showed a marked increase in sensitivity to kindling-induced seizure