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FLASH GENE

Symbol

FBP1

contributors: mct - updated : 29-11-2019

HGNC name	fructose-1,6-bisphosphatase 1
HGNC id	3606

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

FBP1D

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   may repress tumor growth, migration and glycolysis via targeting HIF1A in basal-like breast carcinoma tumoral     --over   is a critical modulator in breast cancer progression by altering glucose metabolism and the activity of WNT/CTNNB1 pathway

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	potential use of the methylation status detected in FBP1 promoter region as a novel predictor for prognosis and therapeutic target for NSCLC (Non-Small Cell Lung Cancer) patients
Therapy target
	System Type Disorder Pubmed cancer brain glioma/neuroblstoma FBP1 is a potential therapeutic target regulating glioblastoma (GBM) metabolism following radiotherapy cancer endocrine pancreas disrupting the CBX3-FBP1 signaling axis would be effective to treat pancreatic cancer and prevent aerobic glycolysis

ANIMAL & CELL MODELS