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FLASH GENE

Symbol

NRF1

contributors: mct/shn - updated : 28-08-2017

HGNC name	nuclear respiratory factor 1
HGNC id	7996

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

related resource

MITOP database

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function results in decreased HERPUD1 expression in cells and liver tissues constitutional     --low   NRF1 and COX6C are down-regulated in Chronic kidney disease (CKD) patients

Susceptibility

to type 2 diabetes mellitus

Variant & Polymorphism other	haplotypes associated with type 2 diabetes mellitus

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

expression levels of NRF1 is significantly decreased in both Alzheimer's disease hippocampal tissues and AD-causing amyloid precursor protein mutant cells