| SUBCELLULAR LOCALIZATION
| extracellular
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytosolic
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| intracellular,nucleus,nucleoplasm
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| text
| primarily a membrane-bound protein localized in the endoplasmic reticulum |
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deletion of N-terminal domain resulted in a predominantly nuclear localization that significantly increased the activation of reporter gene expression |
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targeted to the endoplasmic reticulum (ER), implying that it translocates into the nucleus in response to an activating signal  |
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is integrated within endoplasmic reticulum (ER) membranes through its NHB1-associated TM1 in cooperation with other semihydrophobic amphipathic regions |
| basic FUNCTION
| regulates expression of genes involved in mitochondrial function, and coregulates a large number of E2F target genes |
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respiratory factor 1, involved in the regulation of mitochondrial biogenesis and in oxidative phosphorylation |
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implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication |
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regulate neuronal differentiation, and this function is mediated partly via its downstream IAP gene |
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transcription factor that acts on nuclear genes encoding respiratory subunits and components of the mitochondrial transcription and replication machinery |
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dominant transcription factor regulating mitochondrial biogenesis and respiration |
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central transcription factor that promotes the expression of nuclear-encoded respiratory genes |
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could be a regulatory factor for gene expression of the other visinin-like subfamily members including HPCAL4, HPCAL1, HPCA, and NCALD |
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pivotal transcriptional modulator controlling gene expression of mitochondrial proteins |
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transcriptional inhibitor of the human ACACB gene promoter in the mammalian heart |
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major inducible transcriptional regulator of SLC46A1 gene expression |
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its activity in the minimal SLC46A1 promoter is not essential for the transactivation capacity of upstream enhancer elements in the SLC46A1 promoter |
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functionally regulates mediators of energy consumption in neurons |
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regulates key Na(+)/K(+)-ATPase subunits and plays an important role in mediating the tight coupling between energy consumption, energy generation, and neuronal activity at the molecular level |
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fulfils important functions in maintaining cellular homeostasis and organ integrity |
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is important in cellular stress pathway |
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NRF1 acts through antioxidant response elements located in the HERPUD1 promoter |
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transcription factor NRF1 occupies several thousand additional sites in the unmethylated genome, resulting in increased transcription; restoring de novo methyltransferase activity initiates remethylation at these sites and outcompetes NRF1 binding |
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likely is a key player in the regulation of the ER stress response in cells |
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transcriptional regulation factor that plays a central role in the regulation of mitochondrial biogenesis |
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might act as a novel renal fibrosis antagonist by down-regulating fibrosis signaling in renal fibroblast cells |
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key transcription factor for mitochondrial biogenesis, cooperated with DNA methylation to directly regulate the expression of multiple germ cell-specific genes including ASZ1 |
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role of NRF1 in spermatogenesis |
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NRF1 regulates likely the expression of CXCR4 in normal retinal development and in pathologic processes of retinal hypoxia and neovascularization |
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novel functions of the NGLY1-NRF1 pathway in mitochondrial homeostasis and inflammation |
