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FLASH GENE

Symbol

CALCR

contributors: mct/npt - updated : 04-04-2020

HGNC name	calcitonin receptor
HGNC id	1440

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   from early cardiac development causing an abnormality of the conduction system and cardiac edema

Susceptibility

to bone osteoporosis to Kidney Stone Disease (KSD)

Variant & Polymorphism other	polymorphism associated with bone resorption
	potential association between 3'UTR+18C>T and intron 1 polymorphisms in the CALCR and the risk of kidney stone disease
	rs1801197 could definitely be considered as one of the risk factors for KSD in Indian population

Candidate gene
Marker	high Calcitonin /CALCR expression in primary prostate tumors may serve as a prognostic indicator of disease aggressiveness and poor clinical outcome
Therapy target
	System Type Disorder Pubmed cancer reproductive prostate prevention of CALCR-TJP1 interaction abolishes calcitonin-induced invasion, and can serve as a novel therapeutic tool to treat aggressive prostate cancers

ANIMAL & CELL MODELS