basic FUNCTION
| seven transmembrane segments (7TM) receptor, coupling with Gs alpha protein and activating adenylate cyclase |
|
calcium-binding chaperone, playing a critical role in the regulation of calcium homeostasis |
|
regulates calcium metabolism and bone resorption by osteoclasts (Cafforio 2009) |
|
its expression may contribute to the modulation of cytoplasmic calcium levels needed to regulate T and B cell activation and perhaps other immune functions (Cafforio 2009) |
|
protects against hypercalcemia predominantly via its inhibitory action on osteoclasts |
|
physiological role for the CALCR to protect the maternal skeleton during lactation by a direct action on osteocytes to inhibit osteolysis |
|
CALCR is critical for sustaining quiescence in muscle satellite (stem) cells (MuSCs) |