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FLASH GENE
Symbol CALCR contributors: mct/npt - updated : 04-04-2020
HGNC name calcitonin receptor
HGNC id 1440
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • G protein coupled receptor superfamily
  • secretin receptor subfamily
    • CATEGORY chaperone/stress , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • seven transmembrane segments (7TM) receptor, coupling with Gs alpha protein and activating adenylate cyclase
  • calcium-binding chaperone, playing a critical role in the regulation of calcium homeostasis
  • regulates calcium metabolism and bone resorption by osteoclasts (Cafforio 2009)
  • its expression may contribute to the modulation of cytoplasmic calcium levels needed to regulate T and B cell activation and perhaps other immune functions (Cafforio 2009)
  • protects against hypercalcemia predominantly via its inhibitory action on osteoclasts
  • physiological role for the CALCR to protect the maternal skeleton during lactation by a direct action on osteocytes to inhibit osteolysis
  • CALCR is critical for sustaining quiescence in muscle satellite (stem) cells (MuSCs)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAMP1, RAMP3 inducing specific and high-afffinity binding of amylin (IAPP)
  • interacts with GPRASP2
  • ligands CALCA and RAMP1, novel class of ligands that activate CR exclusively in an autocrine manner (Chang 2010)
  • CALCA stimulates angiogenesis directly by activating CGRP receptors (CALCR)
  • CALCR interacts with zonula occludens 1 (TJP1) through PDZ interaction to destabilize tight junctions and increase invasion of prostate cancers (PCs) cells
    • cell & other
    REGULATION
    activated by activated by the peptide hormones calcitonin and amylin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    from early cardiac development causing an abnormality of the conduction system and cardiac edema
    Susceptibility
  • to bone osteoporosis
  • to Kidney Stone Disease (KSD)
    • Variant & Polymorphism other
  • polymorphism associated with bone resorption
  • potential association between 3'UTR+18C>T and intron 1 polymorphisms in the CALCR and the risk of kidney stone disease
  • rs1801197 could definitely be considered as one of the risk factors for KSD in Indian population
    • Candidate gene
    Marker
  • high Calcitonin /CALCR expression in primary prostate tumors may serve as a prognostic indicator of disease aggressiveness and poor clinical outcome
    • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    prevention of CALCR-TJP1 interaction abolishes calcitonin-induced invasion, and can serve as a novel therapeutic tool to treat aggressive prostate cancers
    ANIMAL & CELL MODELS