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FLASH GENE
Symbol CALCR contributors: mct/npt - updated : 04-04-2020
HGNC name calcitonin receptor
HGNC id 1440
Location 7q21.3      Physical location : 93.053.798 - 93.204.042
Synonym symbol(s) CRT, CTR, CTR1
DNA
TYPE functioning gene
STRUCTURE 150.24 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure
  • two regions in the 5prime-flanking sequence that regulated CALCR gene expression in osteoclasts ( both of these putative promoters were responsive to the osteoclast-inducing cytokine, receptor activator of NF-kappaB ligand TNFSF11) (Shen 2007
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3572 - 474 - 2004 15563840
    16 splicing 3696 - 508 - 2004 15563840
  • also called T42D cells
  • lacking 16aa in the first extracellular loop
  • 13 splicing initiation site 3610 - 474 - 2004 15563840
    lacking 16aa as T47D and 47aa in the N terminal extracellular domain
    - splicing 1523 - 290 giant cell tumor 2004 15563840
  • also called HCTR5
  • deleted from the putative fourth transmembrane domain to C-tail
  • presence of a previously known 16-aa insert in the putative first intracellular loop
  • - splicing 1475 - 274 in giant cell tumor, in TT cells and kidney tissue 2004 15563840
  • also called HCTR6
  • deleted from the putative fourth transmembrane domain to C-tail
  • absence of a previously known 16-aa insert in the putative first intracellular loop
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Reproductivefemale systembreastmammary gland  
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skeletonosteoclast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text highly in the developing heart
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • secretin receptor subfamily
  • CATEGORY chaperone/stress , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • seven transmembrane segments (7TM) receptor, coupling with Gs alpha protein and activating adenylate cyclase
  • calcium-binding chaperone, playing a critical role in the regulation of calcium homeostasis
  • regulates calcium metabolism and bone resorption by osteoclasts (Cafforio 2009)
  • its expression may contribute to the modulation of cytoplasmic calcium levels needed to regulate T and B cell activation and perhaps other immune functions (Cafforio 2009)
  • protects against hypercalcemia predominantly via its inhibitory action on osteoclasts
  • physiological role for the CALCR to protect the maternal skeleton during lactation by a direct action on osteocytes to inhibit osteolysis
  • CALCR is critical for sustaining quiescence in muscle satellite (stem) cells (MuSCs)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAMP1, RAMP3 inducing specific and high-afffinity binding of amylin (IAPP)
  • interacts with GPRASP2
  • ligands CALCA and RAMP1, novel class of ligands that activate CR exclusively in an autocrine manner (Chang 2010)
  • CALCA stimulates angiogenesis directly by activating CGRP receptors (CALCR)
  • CALCR interacts with zonula occludens 1 (TJP1) through PDZ interaction to destabilize tight junctions and increase invasion of prostate cancers (PCs) cells
  • cell & other
    REGULATION
    activated by activated by the peptide hormones calcitonin and amylin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    from early cardiac development causing an abnormality of the conduction system and cardiac edema
    Susceptibility
  • to bone osteoporosis
  • to Kidney Stone Disease (KSD)
  • Variant & Polymorphism other
  • polymorphism associated with bone resorption
  • potential association between 3'UTR+18C>T and intron 1 polymorphisms in the CALCR and the risk of kidney stone disease
  • rs1801197 could definitely be considered as one of the risk factors for KSD in Indian population
  • Candidate gene
    Marker
  • high Calcitonin /CALCR expression in primary prostate tumors may serve as a prognostic indicator of disease aggressiveness and poor clinical outcome
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    prevention of CALCR-TJP1 interaction abolishes calcitonin-induced invasion, and can serve as a novel therapeutic tool to treat aggressive prostate cancers
    ANIMAL & CELL MODELS