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FLASH GENE

Symbol

PTPRZ1

contributors: mct - updated : 05-11-2013

HGNC name	protein tyrosine phosphatase, receptor-type, Z polypeptide 1
HGNC id	9685

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in a number of tumors and has been implicated in glioblastoma pathogenesis

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Ptprz-deficient adult mice display impairments in spatial and contextual learning
	Ptprz-deficient mice show that the binding of Ptprz to Cntn1 expressed at the surface of oligodendrocyte precursor cells inhibits their proliferation and promotes their development into mature oligodendrocytes