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FLASH GENE

Symbol

PTGDS

contributors: mct - updated : 17-05-2011

HGNC name	prostaglandin D2 synthase 21kDa (brain)
HGNC id	9592

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	9q34.3      Physical location : 139.871.955 - 139.876.193
Synonym name	lipocalin-type prostaglandin D synthase
	PGD2 synthase
	glutathione-independent PGD synthase
	prostaglandin H2 D-isomerase
	prostaglandin D synthase
	beta-trace protein
	cerebrin-28
Synonym symbol(s)	PDS, PGD2, PGDS, PGDS2, L-PGDS, DP, L-PGDS
EC.number	5.3.99.2

DNA

TYPE	functioning gene
SPECIAL FEATURE	head to head
STRUCTURE	5.19 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 7 - 837 isoform 1 - 190 - Fujimori (2007)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune B cell Lymphoid/Immune dendritic cell Lymphoid/Immune macrophage

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to rattus Ptgds

Homologene

FAMILY	calycin superfamily
	lipocalin family

CATEGORY

enzyme , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,nucleus

basic FUNCTION	glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2)
	involved in the regulation of non-rapid eye movement sleep
	newly identified melanocyte marker
	play important roles in both maturation and maintenance of the central nervous system and male reproductive system
	PTGDS and its receptor chemoattractant receptor homologous molecule expressed on T(h)2 cells (GPR44) have been implicated in the pathogenesis of numerous allergic diseases
	new regulator of tumor vascular permeability
	in addition to promoting the recruitment and activation of Th2 cells, may also impede the resolution of allergic inflammation through inhibiting apoptosis of Th2 cells
	beneficial for protecting the brain against transient and permanent cerebral ischemia
	catalyses the formation of prostaglandin D(2) (PGD(2)) and also functions as a transporter for lipophilic ligands, including all-trans retinoic acid (RA)
	lipocalin-type enzyme involved in the metabolism of arachidonic acid and plays a key role in the regulation of sleep, allergy, pain sensation, and the development of male reproductive organs

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

induced by

IL-1 beta and thyroid hormone

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in cardiac hypertrophy

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     PTGDS agonism may be exploited as a potential therapy for the treatment of cancer neurology neurodegenerative   utilized as potential targets to prevent damage following either acute or potentially chronic neurological disorders

ANIMAL & CELL MODELS