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FLASH GENE
Symbol GLDC contributors: mct - updated : 06-12-2016
HGNC name glycine dehydrogenase (decarboxylating; glycine decarboxylase, glycine cleavage system protein P)
HGNC id 4313
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY gcvP family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
basic FUNCTION
  • catalyzing the first step of the glycine cleavage system
  • induces dramatic changes in glycolysis and glycine/serine metabolism, leading to changes in pyrimidine metabolism to regulate cancer cell proliferation (PMID;
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NKH1 , GCE2
    related resource MITOP database
    Susceptibility
  • to neural tube defects
    • Variant & Polymorphism other
  • a splice acceptor site mutation and five different non-synonymous variants in GLDC, which were found to significantly impair enzymatic activity and represent putative causative mutations, predisposing to neural tube defects
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS