basic FUNCTION
| able to generate the RNA primers required by DNA polymerase G, to initiate replication of mtDNA |
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playing a roles in early development and postnatal cell injury |
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promoting cell death of non-invasive breast cancer cells |
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mitochondrion-specific nuclease that translocates to the nucleus during apoptosis |
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cleaves chromatin DNA into nucleosomal fragments independently of caspases |
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represents a caspase-independent apoptotic pathway initiated from the mitochondria |
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mitochondrial enzyme, known to be involved in caspase-independent cell death following translocation to the cellular nucleus ![](pubmed.jpg) |
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important role of ENDOG in the senescence program of human endothelial cells ![](pubmed.jpg) |
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role for ENDOG in the generation of S region DSBs and class switch DNA recombination (CSR) ![](pubmed.jpg) |
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role for ENDOG in maladaptive cardiac hypertrophy ![](pubmed.jpg) |
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ENDOG and TOP2A may actively participate in apoptotic chromatin degradation ![](pubmed.jpg) |
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largely related with a role in the modulation of a caspase-independent cell death pathway in many cellular systems ![](pubmed.jpg) |
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could play a highly specific role in the regulation of anxiety by modulating synaptic components ![](pubmed.jpg) |
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is a mitochondrially localized nuclease that triggers DNA degradation and cell death upon translocation from mitochondria to the nucleus ![](pubmed.jpg) |
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ENDOG is a critical downstream executor of SNCA cytotoxicity ![](pubmed.jpg) |
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is responsible for DNA fragmentation both during and after cell death ![](pubmed.jpg) |