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FLASH GENE
Symbol RFC2 contributors: mct - updated : 30-11-2010
HGNC name replication factor C (activator 1) 2, 40kDa
HGNC id 9970
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PCNA binding region,an ATP binding domain
  • a DEAD/H box (Asp-Glu-Ala-Asp/His)
    • mono polymer heteromer , pentamer
    HOMOLOGY
    interspecies homolog to murine Rfc2
    homolog to Drosophila rfc40
    homolog to C.elegans rfc-2
    intraspecies
    Homologene
    FAMILY
  • activator 1 small subunits family
  • AAA+ family of ATPase and ATPase-like proteins
    • CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • activator of DNA polymerases
    • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of complex A-1,DNA polymerase accessory protein "clamp loader", ATP dependent, required to assemble PCNA and polymerase delta on the DNA template
  • complex ATAD5-RFC2-RFC5 functions in a fundamental DNA metabolism to suppress genomic instability
  • heteropentamer of subunit of 140/145, 40,38, 37 and 36.5 kDa (RFC is a pentamer comprising a large subunit, RFC1, and four small subunits, RFC2-RFC5)
    • INTERACTION
    DNA binding
    RNA
    small molecule nucleotide,
  • ATP
    • protein
  • binding to PCNA
    • cell & other
    REGULATION
    activated by BCR/ABL
    Other regulated by RPA1 (plays a regulatory role in DNA damage responses via repression of RFC2 ubiquitylation in cells)
    ASSOCIATED DISORDERS
    corresponding disease(s) WBS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS