basic FUNCTION
| transcription factor involved in strictly maternal transmission of mtDNA in the maintenance of mitochondrial genome |
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playing a role in direct regulation of mitochondrial DNA copy number |
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playing an essential role for transcription initiation and replication of mitochondrial DNA |
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crucial for mitochondrial biogenesis during development and differentiation |
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required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase |
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is able to unwind and bend DNA |
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essential for mtDNA transcription and for mtDNA packaging in mtDNA maintenance |
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essential for the maintenance of mtDNA |
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required for both transcription from and maintenance of mitochondrial genomes |
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functions in both nuclei and mitochondria to promote cell growth |
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may regulate nuclear gene expression and/or chromatin structure in addition to its mitochondrial role |
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is required for mitochondrial DNA (mtDNA) replication and transcription |
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abundant protein that binds and bends promoter DNA 15-40& |
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8201;base pairs upstream of the transcription start site, and stimulates the recruitment of POLRMT and TFB2M to the promoter |
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organization of TFAM, POLRMT and TFB2M around thelight-strand promoter (LSP), represent the first structural characterization of the entire mitochondrial transcriptional initiation complex |
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TFAM first recruits POLRMT to the promoter, followed by TFB2M binding and induction of promoter melting |
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transcription factors TFAM and TFB2M assist mtRNAP to achieve promoter-dependent initiation of mitochondrial transcription |
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is a key regulator of mitochondria biogenesis |
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