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FLASH GENE
Symbol KRT14 contributors: mct - updated : 29-05-2013
HGNC name keratin 14
HGNC id 6416
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • conserved central rod domain, made of four helical domains (1A, 1B, 2A, 2B) interrupted by non alpha helical linkers (L1, 2, 3)
  • flanked by the homology domain H1
  • by variable region (V1, V2)
  • end sequences (E1, E2)
    • secondary structure
  • four helical domains (1A, 1B, 2A, 2B)
  • non alpha helical linkers (L1, 2, 3)
    • mono polymer heteromer , dimer , tetramer
    HOMOLOGY
    interspecies homolog to rattus Krt1-14 (92.01 pc)
    homolog to murine Krt14 (92.93 pc)
    Homologene
    FAMILY
  • intermediate filament family
  • type I keratin family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,intermed filament
    intracellular,nucleus
    text
  • expressed in mitotically active basal layer cells, along with its partner KRT5, and their expression is down-regulated as cells differentiate
    • basic FUNCTION
  • forming the cytoskeleton of epithelial cells
  • cytoplasmic intermediate filament protein preferentially expressed by epithelial tissues in a site-specific and differentiation-dependent manner
  • KRT5 and KRT14 may have a role in maintenance of cell proliferation potential in the basal layer of stratified epithelia, modulating phosphatidylinositol 3-kinase/Akt-mediated cell proliferation and/or NOTCH1-dependent cell differentiation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text epidermis development
    PATHWAY
    metabolism
    signaling
    a component
  • heterotetramer of two type I and two type II keratins
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • KRT5
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EBS2B , EBS3B , EBS5B , DPIR , NFJ
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    dermatologyskin 
    treatments based on thyroid hormone and IFN-gamma that suppress promoter activity could become effective agents in therapy for patients with EBS (epidermolysis bullosa simplex)
    ANIMAL & CELL MODELS