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| Notch1 mutant and Notch1/Notch4 double mutant mouse embryos displayed severe defects in angiogenic vascular remodeling | |
ablation of Notch1 in mouse skin resulted in epidermal and corneal hyperplasia followed by the development of skin tumors and facilitated chemical-induced skin carcinogenesis |
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doubly mouse embryos mutant for Notch1 and Notch2 exhibited multiple defects in left-right asymmetry |
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Notch1 -/- corneal progenitor mouse cells lost the ability to repair mechanically wounded corneal epithelium |