| protein
| NUMB (negative regulator of NOTCH1 activity) |
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interacting with DTX1, DTX2, MAML1, MAMOL2, MAML3, DNER, RBPSUH |
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negative regulation of ROCK1/2 and MRCKalpha kinases |
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regulatory circuit linking NOTCH1 signaling with PTEN expression and PI3K-AKT activity may contribute to NOTCH1-induced transformation and could mediate, at least in part, the cellular response to NOTCH1 inhibitors in T-ALL |
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upregulating the genes encoding cyclin D, cyclin E and SP7 (osterix) |
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interacting with NKX2.5, a novel target gene of NOTCH1 (NKX2.5 is an early event in the growth of embryonic myocytes but its role in the postnatal heart remained unclear) |
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TP53 target with a role in tumor suppression through negative regulation of Rho effectors ROCK1/2 and CDC42BPA |
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F3/contactin acts as a functional ligand of Notch1 |
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Delta like 4 (DLL4, Delta family of Notch ligands) |
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SEL-10 interacts with nuclear forms of Notch1 it requires a phosphorylation event |
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Glycogen synthase kinase 3 beta (GSK3beta) |
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Numb protein promotes the ubiquitination of membrane-bound Notch1 receptor and its intracellular domain degradation following activation |
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Delta1, Jagged1, and Jagged2 |
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histone acetyltransferases PCAF and GCN5 |
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tyrosine kinase p56(lck) and phosphatidylinositol 3-kinase (PI3K) |
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recombination signal binding protein Jkappa (RBP-Jkappa) and Mastermind like 1 (MAML1) |
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interacts with nuclear factor-kappa B proteins in T cells |
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Nephroblastoma overexpressed gene (NOV/ccn3) |
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m-Numb, transcription factor RBP-J kappa/Su(H) |
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Smad3, transcription factor Ying Yang 1 (YY1) |
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Transcriptional coactivator RBP, WDR12, presenilin-1 (PS1) |
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Ski-interacting protein (SKIP) |
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interaction with HUWE1 (ubiquitin ligase HUWE1 operates upstream of the MYCN-DLL3-NOTCH1 pathway to control neural stem cell activity and promote neurogenesis) |
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Crbp1 (RBP1)a direct Notch1 target within the corneal epithelium |
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peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (PIN1) |
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NOTCH1 in concert with NOTCH2 contributes to the morphogenesis of renal vesicles into S-shaped bodies in a RBPJ-dependent manner |
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TLX1 and NOTCH synergistically regulate transcription in T-ALL, at least in part via the sharing of a TLE corepressor and by augmenting expression of MYC |
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AKT1 and FOXM1 are downstream targets of NOTCH1 signaling |
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SGK1 inhibits the NOTCH1 signaling pathway via phosphorylation of FBXW7 |
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DLL3 interacts with the unprocessed full-length form of NOTCH1 (NOTCH1 inhibition by DLL3 implicated in abnormal vertebral segmentation in spondylocostal dysostosis) |
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NOTCH1 activation induces RUNX3 expression in human endothelial cells |
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neuronal NOTCH1 signaling is positively regulated by ARC, an activity-induced gene required for synaptic plasticity |
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JARID2 is a potential regulator of NOTCH1 signaling |
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SIRT1 associates with ICD and functions as a ICD deacetylase, which opposes the acetylation-induced ICD stabilization |
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binds preferentially to promoters, to RBPJ binding sites, and near imputed ZNF143, ETS, and RUNX sites |
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APBB1 attenuates NOTCH1 signaling via the accelerated degradation of the membrane-tethered NOTCH1 in the cytoplasm |
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NOTCH1 directly regulates the transcription of NRG1 by binding to its promoter region |
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EIF6 is one of the downstream effectors of NOTCH1 in the pathway that controls cell motility and invasiveness |
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both NOTCH1 and KDR modulate FLT4 protein and activation levels independently and in opposite directions |
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NOTCH1-FURIN interaction is regulated by the non-receptor tyrosine kinase, SRC |
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IL7R is a transcriptional target of NOTCH1 |
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USP12 directly targets NOTCH1 and directs it to lysosomal degradation |
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CAMK2A is crucial for the regulation between NOTCH1 and WNT5A signaling |
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NOTCH1 intracellular domain increases cytoplasmic EZH2 levels during early megakaryopoiesis |
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KDM1A functions as a corepressor when associated with RBPJ-repressor complex and as a NOTCH1 coactivator upon NOTCH1 activation |
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acts as a NOTCH1 coactivator and plays a role in transcriptional activation events subsequent to ICN1 (intracellular active form of NOTCH1) recruitment that are required for RNAPII assembly at several NOTCH1-responsive loci |
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CAMK4 remarkably increased NOTCH1-intracellular domain stability, and the kinase activity of CAMK4 was essential for facilitating NOTCH1 signaling |
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endothelial cell-derived NO is a regulator of NOTCH1 signaling in aortic valve interstitial cells (AVICs) in the development of the aortic valve and adult aortic valve disease |
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mosaic expression of FOXN4 and proneural factors may serve as the trigger to initiate asymmetric DLL4-NOTCH1 and subsequent BMP/TGFB1 signaling events required for neuronal diversity in the V2 interneurons domain |
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NOV is a non-canonical NOTCH1 ligand |
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SNAI1-DLL4/NOTCH1 axis controls embryonic vascular development |
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FABP4 induction by VEGFA was reduced by blockade of DLL4 binding to NOTCH1 or inhibition of NOTCH1 signal transduction |
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ACVRL1 synergises with NOTCH1 in stalk cells to induce expression of the NOTCH1 targets HEY1 and HEY2 and thereby represses tip cell formation and angiogenic sprouting |
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inhibits chondrogenic differentiation of mesenchymal progenitor cells by targeting TWIST1 |
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LOXL2 is a direct repressor of NOTCH1, and represses NOTCH1 expression in the skin to promote squamous cell carcinoma progression |
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NOTCH1 regulates MGP and calcification gene networks in human valve endothelium |
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activated NOTCH1 leads to pronounced accumulation of SMO within primary cilia and elevated levels of full-length GLI3 |
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IL1B regulates NOTCH1 and NOTCH4 activity in opposite directions, consistent with a selective targeting of NOTCH1 in inflamed endothelium |
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CTF1 activates NOTCH1 signaling through the up-regulation of ADAM10, a rate-limiting factor of NOTCH1 signaling activation |
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JAG1-mediated NOTCH1 signaling regulates differentiation of Basal cells (BC) into secretory cells |
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KRT8 regulates NOTCH1 signalling activity and differentiation in the epithelium of the large intestine |
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MAGEA1 reduced intracellular segment of NOTCH1 receptor (NICD1) stability by promoting the ubiquitin modification of NICD1, and interacted with FBXW7, subunit of E3 ubiquitin protein ligase complex SCF, and the latter was functionally involved in NICD1 ubiquitination and degradation |
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upon ligand binding, NOTCH1 at the cell surface was ubiquitylated by the E3 ubiquitin ligase DTX4 |
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in colorectal cancer, MFNG imposes a negative correlation between JAG1 and NOTCH1, being high JAG1 in the absence of MFNG predictive of poor prognosis |
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LEF1 could activate the critical members (NOTCH1 and NOTCH2) of the NOTCH signaling pathway through directly binding to their promoter regions |
