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FLASH GENE

Symbol

SYK

contributors: mct/npt - updated : 03-03-2016

HGNC name	spleen tyrosine kinase
HGNC id	11491

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral         absent in invasive breast carcinoma tumoral       gain of function in 44p100 primary diffuse large B-cell lymphoma tissues ( constitutional         loss of Syk kinase-mediated integrin signaling impairs leukocyte activation, leading to reduced host defense responses

Susceptibility

Variant & Polymorphism

Candidate gene	may act as potential therapeutic target for the treatment of breast cancer
	SYK inhibition could be beneficial for treatment of disorders including rheumatoid arthritis, allergic rhinitis, and asthma
Marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   SYK kinase inhibition is suggested as a powerful tool for the therapy of different pathologies cancer hemopathy   SYK inhibition as a potentially useful therapy for diffuse large B-cell lymphoma

ANIMAL & CELL MODELS