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FLASH GENE

Symbol

VAV2

contributors: mct - updated : 11-01-2017

HGNC name	vav 2 guanine nucleotide exchange factor
HGNC id	12658

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to obesity, and HTA

Variant & Polymorphism other	carrier of the T allele in VAV2 rs602990 polymorphism is associated with an increased risk of obesity, reduced levels of ankle-brachial index and diastolic blood pressure and reduced retinal artery caliber

Candidate gene	EGFR/VAV2 signaling is involved in cell invasion in head and neck squamous cell carcinoma (Patel 2007)
Marker
Therapy target

ANIMAL & CELL MODELS