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FLASH GENE

Symbol

IFNA2

contributors: mct - updated : 30-05-2015

HGNC name	interferon, alpha 2
HGNC id	5423

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to C.elegans y54g2a.t

Homologene

FAMILY

interferon alpha,beta and delta family

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION

basic FUNCTION

IFNL1, and IFNA2 differ in their ability to modulate IL12 production by TLR-activated macrophages and exhibit differential regulation of the IFNGR1 expression

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

RS4 is a novel USP18-binding protein that can be used to boost the host innate immunity to control HCV, and potentially other viruses that are sensitive to IFNA2

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS