Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

IFNA1

contributors: mct/npt - updated : 03-04-2020

HGNC name	interferon, alpha 1
HGNC id	5417

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   IFNA1 signaling is highly activated in systemic lupus erythematosus (SLE) B cells and plays a vital role in the antibody response by B cell constitutional     --over   in neuromyelitis optica (NMO) patients, with higher frequency in NMO patients with acute relapse

Susceptibility

to systemic lupus erythematosus (SLE) to chronic hepatitis B virus infection

Variant & Polymorphism SNP	A allele of -1823G/A SNP within IFNA1 gene was significantly associated with an increased risk of chronic HBV infection as compared to healthy individuals

Candidate gene
Marker	high serum IFNA1 is a heritable risk factor for SLE
Therapy target
	System Type Disorder Pubmed diabete type 1   due to its central role in the early phases of beta cell death, targeting IFNA1 and its pathways in genetically predisposed individuals may represent a potential novel therapeutic strategy in the very early stages of T1D

ANIMAL & CELL MODELS