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FLASH GENE

Symbol

PMS2

contributors: mct - updated : 05-05-2010

HGNC name	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
HGNC id	9122

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

HNPCC4 , CMMRD

related resource

International Group on Hereditary Non-Polyposis Colorectal Cancer

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function in colon and uterus tumor

Susceptibility

to prostate cancer

Variant & Polymorphism SNP , other	three SNP causing defective protein-protein interaction with MLH1
	rare genetic variants that confer a high risk of prostate cancer when mutated

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS