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FLASH GENE

Symbol

DLX6

contributors: npt/mct - updated : 02-04-2019

HGNC name	distal-less homeobox 6
HGNC id	2919

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SHFM1 , DEL7Q21

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in endometriotic lesions tumoral     --over   in endometriod adenocarcinomas

Susceptibility

to autistic spectrum disorder (ASD)

Variant & Polymorphism other	a G656A base change (R219H) associted with ASD

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Dlx5/Dlx6 double mutants exhibit hindlimb ectrodactyly
	Dlx5/6-inactivation in the mouse results in a phenotype reminiscent of NTDs characterized by open thoracic and lumbar vertebral arches and failure of epaxial muscle formation at the dorsal midline