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FLASH GENE
Symbol HNRNPA2B1 contributors: mct/npt - updated : 07-05-2010
HGNC name heterogeneous nuclear ribonucleoprotein A2/B1
HGNC id 5033
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two RNA recognition motif (RRM) domains
    • conjugated RiboP
    HOMOLOGY
    interspecies ortholog to rattus LOC362361
    ortholog to murine Hnrpa2b1
    Homologene
    FAMILY
  • heterogeneous nuclear ribonucleoproteins (hnRNPs) family
  • A/B subfamily
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • involved in mRNA processing and nuclear-cytoplasm transport
  • housekeeping genes possessing a dominant ubiquitously-acting chromatin opening element (UCOE) capability (Lindahl Allen 2007)
  • with PTBP1, and HNRNPA1, have critical role in promoting PKM2 production in tumours, and overexpression of some combination of them is, like PKM2 expression, likely to be a general phenomenon in cancer (David 2010)
  • common transcriptional coactivator in the nuclear transcription response to mitochondrial respiratory stress (Guha 2009)
  • regulates alternative mRNA splicing of TP53INP2 to control invasive cell migration (Moran -Jones 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • associates with the enhanceosome, mostly through protein-protein interactions with DNA-bound factors (Guha 2009)
    • cell & other
    REGULATION
    Other phosphorylated by AKT1 under mitochondrial stress conditions, which is a crucial step for the recruitment of this coactivator to the stress target promoters and culmination in mitochondrial stress-mediated transcription activation of target genes (Guha 2010)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gliomas, in a manner that correlates with PKM2 expression (David 2010)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS