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FLASH GENE

Symbol

HNRNPA2B1

contributors: mct/npt - updated : 07-05-2010

HGNC name	heterogeneous nuclear ribonucleoprotein A2/B1
HGNC id	5033

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002137 11 splicing 3666 NP_002128 - 341 - - NM_031243 12 splicing 3702 NP_112533 37 353 - -

EXPRESSION

Type

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel         Digestive intestine large intestine colon     Gustatory (taste) tongue         Lymphoid/Immune thymus         Nervous brain         Reproductive female system breast mammary gland       female system uterus       Respiratory respiratory tract larynx       Urinary bladder

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two RNA recognition motif (RRM) domains

conjugated

RiboP

HOMOLOGY

interspecies	ortholog to rattus LOC362361
	ortholog to murine Hnrpa2b1

Homologene

FAMILY	heterogeneous nuclear ribonucleoproteins (hnRNPs) family
	A/B subfamily

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,chromatin/chromosome
	intracellular,nucleus,nucleolus

basic FUNCTION	involved in mRNA processing and nuclear-cytoplasm transport
	housekeeping genes possessing a dominant ubiquitously-acting chromatin opening element (UCOE) capability (Lindahl Allen 2007)
	with PTBP1, and HNRNPA1, have critical role in promoting PKM2 production in tumours, and overexpression of some combination of them is, like PKM2 expression, likely to be a general phenomenon in cancer (David 2010)
	common transcriptional coactivator in the nuclear transcription response to mitochondrial respiratory stress (Guha 2009)
	regulates alternative mRNA splicing of TP53INP2 to control invasive cell migration (Moran -Jones 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

binding

small molecule

protein

associates with the enhanceosome, mostly through protein-protein interactions with DNA-bound factors (Guha 2009)

cell & other

REGULATION

Other

phosphorylated by AKT1 under mitochondrial stress conditions, which is a crucial step for the recruitment of this coactivator to the stress target promoters and culmination in mitochondrial stress-mediated transcription activation of target genes (Guha 2010)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in gliomas, in a manner that correlates with PKM2 expression (David 2010)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS