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FLASH GENE
Symbol TRHR contributors: mct/npt - updated : 25-03-2009
HGNC name thyrotropin-releasing hormone receptor
HGNC id 12299
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six transmembrane domains
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Trhr
    ortholog to murine Trhr
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
    • CATEGORY signaling hormone , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral membrane protein
    basic FUNCTION
  • thyrotropin releasing hormone receptor
  • neurotransmitter and neuro regulator
  • controlled dimerization of the TRH receptor potentiates hormone-induced receptor trafficking (SONG 2005)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal , signal transduction
    thyroid
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TRHRD
    Susceptibility to low lean body mass (LBM)
    Variant & Polymorphism SNP two SNPs, rs16892496 and rs7832552 , within the thyrotropin-releasing hormone receptor (TRHR) gene were significantly associated with LBM (Liu 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS