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FLASH GENE
Symbol ABCA2 contributors: - updated : 25-11-2005
HGNC name ATP-binding cassette, sub-family A (ABC1), member 2
HGNC id 32
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two ATP binding
  • two transmembrane (2TM) domains (2 x 6 segments)
  • lipocalin signature motif
    • HOMOLOGY
    interspecies homolog to murine Abc2
    intraspecies homolog to ABCA1,ABCA7
    Homologene
    FAMILY ATP binding cassette superfamily, subfamily A
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • ABC transporter, traffic ATPase, involved in drug resistance, macrophage lipid metabolism and neural development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text
  • neural development
  • small molecule transport
    • PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS