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FLASH GENE

Symbol

ABCA2

contributors: - updated : 25-11-2005

HGNC name	ATP-binding cassette, sub-family A (ABC1), member 2
HGNC id	32

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       moderately Cardiovascular heart       moderately Endocrine pancreas       moderately Nervous brain       highly Reproductive male system prostate     moderately Respiratory lung       moderately Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid

cell lineage
cell lines	tumor cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two ATP binding
	two transmembrane (2TM) domains (2 x 6 segments)
	lipocalin signature motif

HOMOLOGY

interspecies

homolog to murine Abc2

intraspecies

homolog to ABCA1,ABCA7

Homologene

FAMILY

ATP binding cassette superfamily, subfamily A

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

ABC transporter, traffic ATPase, involved in drug resistance, macrophage lipid metabolism and neural development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

text	neural development
	small molecule transport

PATHWAY

metabolism

lipid/lipoprotein

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS