| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
| deletion
|
|
|
|
in osteosarcomas and Ewing sarcomas, and in cutaneous large cells lymphoma (marker of apparition and progression), homozygously deleted in any neuroblastomas and in bladder cancer |
| tumoral
|
| LOH
|
|
|
|
in esophageal squamous cell carcinoma (concomitant loss of RB or not) and in hepatocellular carcinoma |
| tumoral
|
|
|
| loss of function
|
|
inactivated by hypermethylation in non small cell lung carcinoma of non-smoker, in melanoma and in pancreas carcinoma |
| tumoral
|
|
|
| gain of function
|
|
activated by hypomethylation in breast cancer |
| tumoral
|
|
|
| loss of function
|
|
loss of function or deletion in ovarian granulosa cell |
| tumoral
|
| deletion
|
|
|
|
-mutated or deleted in non in small cell lung carcinoma of smoker,in squamous cell carcinoma of the skin and esophagus, in vulval squamous neoplasia and in colorectal cancer |
| tumoral
| germinal mutation
| deletion
|
|
|
|
in melanoma |
| tumoral
|
| deletion
|
|
|
with hypermethylation of CpG islands, in acute lymphoblastic leukemia (ALL)  |
| tumoral
|
| deletion
|
|
|
|
minimal common deleted region removing CDKN2A exon 1 and CDKN2B exon 2 in diffuse large B-cell lymphomas |
| tumoral
|
|
| --low
|
|
|
by promoter methylation may be closely implicated in the pathogenesis of multiple myeloma (MM) |
