| Symbol
| RXRA
| contributors: mct/npt - updated : 04-04-2019
|
| HGNC name
| retinoid X receptor, alpha
|
| HGNC id
| 10477
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| constitutional
|
|
| --low
|
|
mediates the elevation of PTGS2 expression and PGE2 production in senescent macrophages  | | constitutional
|
|
| --low
|
| |
in senescent macrophages and partially accounts for higher risk of atherosclerosis in aged population | | tumoral
|
|
| --over
|
| |
in Esophageal carcinoma (EC) correlated with unfavorable prognosis | |
| Susceptibility
|
to chronic glomerulonephritis |
| Variant & Polymorphism
SNP
| rs10776909 allele T is specifically involved in the pathogenesis of chronic glomerulonephritis |
| 
|
Candidate gene
Marker
Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| miscelleaneous | senescence | | |
| as a potential therapeutic target for treating the age-related diseases | | immunology | infectious | | |
| represents a potential target for immunotherapy of sepsis | | cancer | digestive | oesophagus | |
| may serve as a potential targeted therapeutic marker in the treatment of EC | | neurosensorial | visual | | |
| RXR agonists might provide potential pharmacological tools for treating retina degenerative diseases | | cancer | skin | | |
| RXRA, RXRB are potential targets for therapy against UV induced melanoma (PMID: 24810760) |
| | | |
|
| activation of Rxrs protects rat photoreceptor neurons from oxidative stress-induced apoptosis |