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FLASH GENE

Symbol

ARHGEF5

contributors: mct - updated : 21-05-2015

HGNC name	Rho guanine nucleotide exchange factor (GEF) 5
HGNC id	13209

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in breast cancer cell lines constitutional       loss of function attenuated allergic airway inflammation tumoral     --over   significantly increased in lung adenocarcinoma tissues and cell lines constitutional     --over   promoted actin stress fiber remodeling through activating RHOA, and the activation of RHOA or CDC42 was required for SRC-induced podosome formation

Susceptibility

Variant & Polymorphism other	five alternative variants predominantly expressed in aggressive primary breast cancer

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS