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FLASH GENE

Symbol

SLC1A1

contributors: mct/npt/shn - updated : 17-04-2016

HGNC name	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
HGNC id	10939

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

related resource

MITOP database

Susceptibility

to Obsessive-Compulsive Disorder

Variant & Polymorphism other	polymorphism increasing the risk of obsessive-compulsive disorder

Candidate gene
Marker
Therapy target	Treatment of the EAAC1(-/-) mice with N-acetyl cysteine restored neuronal glutathione concentrations, normalized basal zinc levels, reduced ischemia-induced zinc translocation, superoxide production, and neuron death

ANIMAL & CELL MODELS

EAAC1(-/-) mice subjected to transient cerebral ischemia exhibited twice as much hippocampal neuronal death, elevated vesicular and cytosolic zinc concentrations in hippocampal CA1 neurons and an increased zinc translocation to postsynaptic neurons after ischemia