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FLASH GENE

Symbol

GTF2E2

contributors: mct - updated : 14-04-2016

HGNC name	general transcription factor IIE, polypeptide 2, beta 34kDa
HGNC id	4651

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine parathyroid       highly Hearing/Equilibrium ear       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a region of RAP 30 (the small subunit of TFIIF) with squence similarity to a sigma-factor subregion implicated in binding to RNA polymerase
	a forkhead motif within the central region, essential for transcription, that possessed a double-stranded DNA-binding activity, and primary function of the forkhead region is dsDNA-binding in transcription with three positively charged lysine AAs which play a key role in this function
	basic region helix-loop-helix (bHLH) motif
	three-winged helix (WH) motifs, with one in GTF2E1 and two in GTF2E2

mono polymer

heteromer , tetramer

HOMOLOGY

interspecies	homolog to murine C330006j08 Rik
	homolog to C.elegans F54D5.11

Homologene

FAMILY

TFIIE beta subunit family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm

basic FUNCTION	ERCC3 recruitment to initiation complex
	stimulating the RNA polymerase II C terminal domain kinase and DNA-dependent ATPase activities of ERCC3
	plays essential roles in both transcription initiation and the transition from initiation to elongation
	has essential roles in both transcription initiation and promoter escape
	transcription factor essential for the assembly and stabilization of the RNA pol II pre-initiation complex (PIC) at the transcription start site

CELLULAR PROCESS	nucleotide, transcription, initiation
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

heterotetramer of two alpha and two beta chains

INTERACTION

DNA

RNA

small molecule

protein	CDK7 thus acts through GTF2E1, GTF2E2 and SUPT5H to establish, and through CDK9 to relieve, barriers to elongation
	IFRD1 plays essential roles in the transition step from transcription initiation to elongation by binding to melted DNA in collaboration with GTF2E2
	IFRD1 is essential for transcription initiation by RNA polymerase II (RNA pol II) via direct interaction with the basal transcription/DNA repair factor IIH (ERCC3)
	GTF2E2 binds to the WH domain of GTF12E1 via its bHLH domain (basic region-helix-loop-helix motif, AAs 193–240)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

TTDRP

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS