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FLASH GENE

Symbol

OPRK1

contributors: mct - updated : 27-01-2016

HGNC name	opioid receptor, kappa 1
HGNC id	8154

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

conjugated

GlycoP , LipoP

HOMOLOGY

Homologene

FAMILY

G protein coupled receptor superfamily

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	plasma membrane
text	localized to nonpigmented ciliary epithelia

basic FUNCTION	opioid receptor kappa, both pre- and post synaptically detected, transported to the axons
	inhibiting a G protein-modulated K+ channel
	EGF-stimulated axon extension during development is mediated, at least partially, by specific elevation of OPRK1 production at posttranscriptional level, as well as activation of OPRK1 signaling
	OPRK1 -mediated reduction in intraocular pression could be caused, in part, by NO production in both the ciliary body and the trabecular meshwork
	OPRK1 activates MAPK14 through a phosphorylation and arrestin-dependent mechanism
	likely modulate GABAergic synaptic responses and ethanol effects as one of multiple opioid system-dependent actions of ethanol in the central amygdala (CeA), possibly in a circuit-specific manner
	during hypoxia, the expression of OPRK1 increased in the pulmonary artery

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

APLN forms a heterodimer with OPRK1 and leads to increased PKC and decreased protein kinase A activity leading to a significant increase in cell proliferation

INTERACTION

DNA

RNA

small molecule

protein	stimulation of OPRK1, the endogenous receptor for the dynorphin-like peptides, inhibits dopamine release in the striatum (nucleus accumbens and caudate putamen) and induces a negative mood state
	addition of OPRK1 agonists to KDR vascular progenitors inhibited endothelial cells differentiation and vascular formation
	YWHAZ promotes expression of the OPRK1 by inhibiting COPI and RVR motif-mediated endoplasmic reticulum localization machinery
	interaction between OPRK1 and its native peptide ligand PDYN
	RGS2 and RGS4 are new interacting partners that play key roles in G protein coupling to negatively regulate OPRK1 signaling
	activation of HCRTR1 was found to attenuate agonist-activated OPRK1-mediated inhibition of cAMP production

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   OPRK1 promoter hypermethylation might increase the risk of Alzheimer through its regulation on the gene expression of OPRK1

Susceptibility

to opiate addiction to alcohol dependence

Variant & Polymorphism SNP , other	36G > T SNP was significantly higher among heroin-dependent individuals compared with control subjects
	polymorphisms increasing the risk of alcohol dependence

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurosensorial visual anterior chamber agonists reduce intraocular pression by reducing aqueous humor formation and increasing aqueous humor outflow, thereby suggesting their possible usefulness in glaucoma therapy

ANIMAL & CELL MODELS

Oprk1 stimulation inhibits TLR4/NfkB signaling in the rat heart subjected to myocardial ischemia and reperfusion (MI/R)