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FLASH GENE
Symbol OPRK1 contributors: mct - updated : 27-01-2016
HGNC name opioid receptor, kappa 1
HGNC id 8154
Location 8q11.23      Physical location : 54.138.275 - 54.164.194
Synonym name opiate receptor, kappa-1
Synonym symbol(s) KOR-1, OPRK, KOR, KOPr
DNA
TYPE like-sequence
STRUCTURE 25.98 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 5196 - 291 - 1995 7869844
4 - 4959 - 380 - 1995 7869844
- - 5022 - 409 - 1995 7869844
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousgangliasensory gangliadorsal root  
Reproductivefemale systemplacenta   
 male systemprostate   
Visualeyeanterior segment    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
conjugated GlycoP , LipoP
HOMOLOGY
Homologene
FAMILY G protein coupled receptor superfamily
CATEGORY receptor
SUBCELLULAR LOCALIZATION     plasma membrane
text
  • localized to nonpigmented ciliary epithelia
  • basic FUNCTION
  • opioid receptor kappa, both pre- and post synaptically detected, transported to the axons
  • inhibiting a G protein-modulated K+ channel
  • EGF-stimulated axon extension during development is mediated, at least partially, by specific elevation of OPRK1 production at posttranscriptional level, as well as activation of OPRK1 signaling
  • OPRK1 -mediated reduction in intraocular pression could be caused, in part, by NO production in both the ciliary body and the trabecular meshwork
  • OPRK1 activates MAPK14 through a phosphorylation and arrestin-dependent mechanism
  • likely modulate GABAergic synaptic responses and ethanol effects as one of multiple opioid system-dependent actions of ethanol in the central amygdala (CeA), possibly in a circuit-specific manner
  • during hypoxia, the expression of OPRK1 increased in the pulmonary artery
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • APLN forms a heterodimer with OPRK1 and leads to increased PKC and decreased protein kinase A activity leading to a significant increase in cell proliferation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • stimulation of OPRK1, the endogenous receptor for the dynorphin-like peptides, inhibits dopamine release in the striatum (nucleus accumbens and caudate putamen) and induces a negative mood state
  • addition of OPRK1 agonists to KDR vascular progenitors inhibited endothelial cells differentiation and vascular formation
  • YWHAZ promotes expression of the OPRK1 by inhibiting COPI and RVR motif-mediated endoplasmic reticulum localization machinery
  • interaction between OPRK1 and its native peptide ligand PDYN
  • RGS2 and RGS4 are new interacting partners that play key roles in G protein coupling to negatively regulate OPRK1 signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    OPRK1 promoter hypermethylation might increase the risk of Alzheimer through its regulation on the gene expression of OPRK1
    Susceptibility
  • to opiate addiction
  • to alcohol dependence
  • Variant & Polymorphism SNP , other
  • 36G > T SNP was significantly higher among heroin-dependent individuals compared with control subjects
  • polymorphisms increasing the risk of alcohol dependence
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurosensorialvisualanterior chamber
    agonists reduce intraocular pression by reducing aqueous humor formation and increasing aqueous humor outflow, thereby suggesting their possible usefulness in glaucoma therapy
    ANIMAL & CELL MODELS
  • Oprk1 stimulation inhibits TLR4/NfkB signaling in the rat heart subjected to myocardial ischemia and reperfusion (MI/R)