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FLASH GENE
Symbol GHRHR contributors: mct/ - updated : 24-08-2007
HGNC name growth hormone releasing hormone receptor
HGNC id 4266
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
    • mono polymer heptamer
    HOMOLOGY
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • secretin family, coupling with Gs alpha protein and activating adenylate cyclase
    • CATEGORY signaling hormone , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text localizes to the surface of somatotroph cells and binds GHRH
    basic FUNCTION
  • stimulating somatotroph cell growth, growth hormone gene transcription and growth hormone secretion
  • can form multimers, which may be important to its signaling properties
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds GHRH
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GHRHR
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS