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FLASH GENE

Symbol

GHRHR

contributors: mct/ - updated : 24-08-2007

HGNC name	growth hormone releasing hormone receptor
HGNC id	4266

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine neuroendocrine pituitary     specific Respiratory respiratory tract trachea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine

cell lineage
cell lines	pituitary adenoma
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

mono polymer

heptamer

HOMOLOGY

Homologene

FAMILY	G protein coupled receptor superfamily
	secretin family, coupling with Gs alpha protein and activating adenylate cyclase

CATEGORY

signaling hormone , receptor

SUBCELLULAR LOCALIZATION	plasma membrane
text	localizes to the surface of somatotroph cells and binds GHRH

basic FUNCTION	stimulating somatotroph cell growth, growth hormone gene transcription and growth hormone secretion
	can form multimers, which may be important to its signaling properties

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal

a component

INTERACTION

DNA

RNA

small molecule

protein

binds GHRH

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

GHRHR

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS