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FLASH GENE

Symbol

GHRHR

contributors: mct/ - updated : 24-08-2007

HGNC name	growth hormone releasing hormone receptor
HGNC id	4266

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	15.51 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 1641 isoform 1 - 359 ubiquitous, normal and tumoral tissues Rekasi (2000) also called SV1 5' region from intron 3, (exon1, 2, 3 missing) variant 2 - - 1487 isoform 2 - 145 pituitary, not expressed in pancreas Rekasi (2000) also called SV2 encode a GHRHR isoform truncated after the second transmembrane domain variant 3 - - 1311 isoform 3 - 151 normal prostate Rekasi (2000) also called SV3 variant 4 - - 1256 isoform 4 - 68 pituitary adenoma Rekasi (2000) also called SV4 NM_000823 13 - 1617 NP_000814 47.3 423 - Pereira (2007) variant 5 - - - isoform 5 - - - McElvaine (2006) also called SV5 protein truncated just before the sixth transmembrane domain acts as a dominant inhibitor of wild-type receptor signaling wild-type and truncated GHRH receptor proteins form a complex

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine neuroendocrine pituitary     specific Respiratory respiratory tract trachea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine

cell lineage
cell lines	pituitary adenoma
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

mono polymer

heptamer

HOMOLOGY

Homologene

FAMILY	G protein coupled receptor superfamily
	secretin family, coupling with Gs alpha protein and activating adenylate cyclase

CATEGORY

signaling hormone , receptor

SUBCELLULAR LOCALIZATION	plasma membrane
text	localizes to the surface of somatotroph cells and binds GHRH

basic FUNCTION	stimulating somatotroph cell growth, growth hormone gene transcription and growth hormone secretion
	can form multimers, which may be important to its signaling properties

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal

a component

INTERACTION

DNA

RNA

small molecule

protein

binds GHRH

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

GHRHR

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS