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FLASH GENE
Symbol GHRHR contributors: mct/ - updated : 24-08-2007
HGNC name growth hormone releasing hormone receptor
HGNC id 4266
Corresponding disease
GHRHR dwarfism with growth hormone deficiency
Location 7p14.3      Physical location : 31.003.635 - 31.019.146
Synonym name
  • GRF receptor
  • growth hormone-releasing hormone receptor form c
  • growth hormone-releasing hormone receptor form a
  • growth hormone-releasing hormone receptor form b
  • Synonym symbol(s) GHRFR, GHRHRpsv, GRFR, IGHD1B, GHRHRpsv
    DNA
    TYPE functioning gene
    STRUCTURE 15.51 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1641 - 359 ubiquitous, normal and tumoral tissues Rekasi (2000)
  • also called SV1
  • 5' region from intron 3, (exon1, 2, 3 missing)
  • - - 1487 - 145 pituitary, not expressed in pancreas Rekasi (2000)
  • also called SV2
  • encode a GHRHR isoform truncated after the second transmembrane domain
  • - - 1311 - 151 normal prostate Rekasi (2000)
    also called SV3
    - - 1256 - 68 pituitary adenoma Rekasi (2000)
    also called SV4
    13 - 1617 47.3 423 - Pereira (2007)
    - - - - - - McElvaine (2006)
  • also called SV5
  • protein truncated just before the sixth transmembrane domain
  • acts as a dominant inhibitor of wild-type receptor signaling
  • wild-type and truncated GHRH receptor proteins form a complex
  • EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  specific
    Respiratoryrespiratory tracttrachea   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines pituitary adenoma
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • mono polymer heptamer
    HOMOLOGY
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • secretin family, coupling with Gs alpha protein and activating adenylate cyclase
  • CATEGORY signaling hormone , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text localizes to the surface of somatotroph cells and binds GHRH
    basic FUNCTION
  • stimulating somatotroph cell growth, growth hormone gene transcription and growth hormone secretion
  • can form multimers, which may be important to its signaling properties
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds GHRH
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GHRHR
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS