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FLASH GENE

Symbol

ADCYAP1R1

contributors: mct - updated : 06-01-2021

HGNC name	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
HGNC id	242

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in macrophages is a common mechanism in response to acute and chronic pro-inflammatory stimuli

Susceptibility

to Cluster Headache (CH) to Posttraumatic stress disorder (PTSD) to severity of social deficits and functional amygdala connectivity in autism spectrum disorder

Variant & Polymorphism	association of CH with a common variant of the PACAP receptor gene (ADCYAP1R1)
	sex-dependent association between ADCYAP1R1 and Posttraumatic stress disorder (PTSD)
	ADCYAP1R1 genotype is linked to severity of social deficits and functional amygdala connectivity in ASD

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS