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| knockout of trkB restricted to the mouse forebrain during postnatal development leads to increasingly impaired learning behavior or inappropriate coping responses when facing complex and/or stressful learning paradigms, impairment LTP at CA1 hippocampal synapses  | |
inhibitory interneurons are strongly affected, express reduced amounts of GABAergic markers and develop reduced numbers of GABAergic boutons and synaptic specializations in cerebellum of TrkB mutant mice |
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mouse mutants that expresses the BDNF receptor TrkB at a quarter of the normal amount showed hyperphagia and excessive weight gain on higher-fat diets |
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trkB(CaMKII-CRE) mice with a trkB-receptor disruption in the forebrain showed a stereotyped hyper-locomotion with reduced explorative activity, and impulsive reactions to novel stimuli |
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in vivo conditional deletion of TrkB from mature motor neurons attenuates mutant superoxide dismutase 1 (SOD1) toxicity |